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Lung cancer symptoms - paraneoplastic syndromes

Neoplasms are an immune system response to the presence of a cancerous tumor. Paraneoplastic syndromes are rare and believed to occur when cancer-fighting antibodies (white blood cells) mistakenly attack normal cells in the nervous system. When one of these syndromes is associated with lung cancer, it is often with small cell lung cancer or because the cancer has metastasized to a particular part of the body. 

Learn about paraneoplastic syndromes

Paraneoplastic syndromes information page (National Institute of Neurological Disorders and Stroke)

Learn about specific paraneoplastic conditions with an association with lung cancer

Clubbing and Hypertrophic Osteoarthropathy (HPOA)

What is finger clubbing? (Cancer Research UK) 

Hypertrophic Osteoarthropathy (MedScape Reference)


Hypercalcemia (Medline Plus) 

Hypercalcemia (Mayo Clinic)

Hyponatremia and related syndrome of inappropriate secretion of antidiuretic hormone (SIADH), also known as Schwartz-Bartter syndrome and syndrome of immoderate antidiuresis (SIAD)

Hyponatremia (Mayo Clinic)

Syndrome of inappropriate antidiuretic hormone (MedScape Reference)

Pancoast Syndrome (superior sulcus tumors)

Pancoast tumor (

Pancoast Syndrome (MedScape Reference)

Superior Vena Cava Syndrome (SVC)

Superior vena cava syndrome (National Cancer Institute)

Superior vena cavea syndrome (Medscape Reference) 

Cushing Syndrome

Cushing syndrome (Medline Plus)

Cushing's syndrome (Mayo Clinic

Lambert-Eaton Syndrome

Lambert-Eaton Syndrome (Medline Plus)

Lambert-Eaton Syndrome (Johns Hopkins Medicine)

Paraneoplastic cerebellar degeneration

Paraneoplastic cerebellar degeneration (Medscape Reference)

Paraneoplastic cerebellar degeneration (Penn's Abramson Cancer Center)

Limbic encephalitis

Paraneoplastic limbic encephalitis (Penn's Abramson Cancer Center)

Limbic encephalitis (Office of Rare Diseases Research)