Benefits and Risks of Clinical Trials

Benefits of Participating

Clinical trials offer you the opportunity to receive the best healthcare available and to help others currently affected by lung cancer and those who will be affected in the future.

You can choose to participate in a clinical trial and still work with your current healthcare team.

Some of the benefits you may derive from participating in a clinical trial include:

• New treatments that may be more effective than the standard treatment are available to you only if you are enrolled in a clinical trial
• Doctors and nurses who will closely monitor your health status and watch very carefully for any side effects and changes in your condition while in the clinical trial
• Part of your treatment may be free of charge
• Satisfaction knowing that your involvement may ultimately help other people
• Knowing that, if one of the treatments being tested (either new or old) is apparently much better than the another, you will be switched to the better treatment

Risks Involved

Great efforts are made to ensure safety for patients participating in clinical trials. Still, risks remain. These risks are greater in Phase I and II studies than in Phase III or IV studies. Discuss possible risks with your doctor. Before you enter a trial, your healthcare provider will talk with you in detail about the risks and benefits of the treatment.

Some patients are concerned that they will be "guinea pigs" for medical science if they participate in a clinical trial. In Phase III cancer clinical trials, the new treatment being tested is compared with the standard treatment. This means that in most cases a patient will be receiving at least standard treatment for their cancer.

If a placebo is used in a trial you will be informed verbally and in writing about your chance of receiving the placebo.

Not all treatments work for all people. Clinical trials offer patients one more treatment option. They represent an opportunity to receive up-to-date treatment and contribute to medical science and humanity at the same time. The good that can come from a clinical trial generally outweighs the risks.

Informed Consent

If you decide to join a clinical trial, you will be asked to sign an informed consent form. This document is required by all institutions. When you sign the informed consent, you are stating that you have discussed the clinical trial with your doctor or nurse, that you have been told about the possible risks and benefits, and that you are participating in the trial because you want and choose to do so of your own free will.